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Animals were housed in specialized high-barrier, specific pathogen-free (SPF) animal rooms, with experimental and control groups co-housed

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Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice

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Moreover, after caloric restriction, obese subjects showed weight loss together with ameliorated IR, reduced ER stress markers and improved mitochondrial function [53], suggesting the link between ER stress and abnormal lipid metabolism/IR