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Future progress will require: (1) Parameter optimization studies: Systematic in vitro screening of DECLARATIONS Authors contribution Writing - original draft, investigation, conceptualization, and funding acquisition: Wang LY Writing - review and editing: Fan MY, Jiang XY, Bing KJ, Wang YJ, Zhang H Writing - review and editing, supervision: Wang KS, Huang YM Availability of data and materials Not applicable

On the other hand, in NAFLD, anti-inflammatory cytokines such as IL-1 receptor antagonist (IL-1RA) and IL-10 reduce tissue damage and have beneficial effects (Ullah et al., 2023a

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