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The non-glycemic effects of incretin therapies on cardiovascular outcomes, cognitive function and bone health

4.4 Podocyte- and tubule-secreted ANGPTL4 activate pro-mesenchymal dipeptidyl peptidase-4-integrin 1 transduction pathway in diabetic kidney Active TGF- signaling and higher dipeptidyl peptidase-4 (DPP-4) levels are causative pathways that accelerate renal fibrosis in diabetes (Srivastava et al., 2020b

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Characterizing lipedema through this lens will be vital for understanding how the disease alters progenitor function and differentiation