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Interestingly, higher concentrations such as 1 mM and 2 mM did not yield similar protective effects, indicating a dose-dependent response and identifying 0.1 mM as the optimal concentration for reactive oxygen species mitigation [2]

Am J Physiol Renal Physiol 2003;284:F1207F1215

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Patients should receive comprehensive education regarding signs and symptoms that could indicate malignancy and should be counseled to report any new symptoms or changes promptly

People with gastrointestinal conditions : Individuals with conditions such as Crohns disease, celiac disease, or those who have undergone gastrointestinal surgery are at higher risk of B12 deficiency