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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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However, benefits were still observed across the BMI spectrum, and the effects were generally consistent across multiple subgroups, including those with mildly reduced versus preserved ejection fraction, and those receiving versus not receiving other heart failure medications like mineralocorticoid receptor antagonists and SGLT2 inhibitors at baseline

Phillip M

Therefore, rational and properly designed experiments that utilize this technology in CKD management are vital

When used with insulin or sulfonylureas, tirzepatide may increase the risk of hypoglycemia, and dosage adjustments of these medications may be necessary