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Metabolomics confirmed this via reduced GSH recycling intermediates (S-lactoylglutathione, cysteine-GSH disulfide) ( A Stat1-Gpx3 hub was identified, where TNF-/IL-1-induced Stat1 activation suppresses Nrf2 (confirmed by reduced hippocampal Nrf2)

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doi: 10.1016/s0006-291x(03)00619-3

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