The cerebrovasculature is a very bioenergetically active tissue with capillary endothelial cells having been shown to possess five times more mitochondria than muscle cells (Oldendorf and Brown, 1975) and transport 10 times their weight in glucose each minute across the BBB, along with accomplishing other energetically costly cellular processes (Cunnane et al., 2011)
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Specifically, we found a statistically significantly smaller reduction in SMR, but not 24h-EE, with SAR425899 (before and after adjustment for change in body weight and body composition)
Exploring their relationship with ferroptosis offers new insights into their potential as therapeutic targets for COPD (125)
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