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It is given as a once-weekly subcutaneous injection, with doses escalated gradually under medical supervision in clinical trials

Improved physical functioning enables engagement in activities known to combat depression, including exercise and social participation

Noteworthy, synergistic effects, while biologically plausible and supported in some settings, may not manifest uniformly in every population or under every protocol

It was a year defined by effect sizes, first-line shifts, and disease-modifying signals that are already changing real clinical decision-making