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A comprehensive search strategy was also conducted in PubMed using both MeSH terms and text words to capture studies involving human subjects and review articles

Further analysis of aged mice testes after FOXO4-DRI treatment revealed a reduction in interstitial SA--gal activity, along with decreased levels of senescence-associated proteins p53, p21, and p16

Clinical trials have included both male and female participants, with some notable observations: Metabolic differences Men typically have higher baseline metabolic rates and different fat distribution patterns, which may influence response magnitude but not optimal dosing protocols

TABLE 1 The scoring criteria of DAI

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