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9 , e0004193 (2015)

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Its mechanism involves modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of cortisol and growth hormone-releasing hormone (GHRH) secretion, and interaction with the GABAergic and glutamatergic systems

1 Introduction The primary focus of medicine in the late 19 th and early 20 th centuries was the management of communicable diseases (Sakai and Morimoto, 2022)