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This fundamental difference in pharmacokinetics explains the superior clinical outcomes with prescription medication

BardetBiedl syndrome, a ciliopathy with autosomal recessive inheritance, is frequently associated with hyperphagia and obesity, in addition to syndromic features such as polydactyly, retinal dystrophy, and renal abnormalities [73]

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Interestingly, patients with higher percentages of GI AE were more likely to achieve greater weight loss