Both products contain overlapping micronutrients, including zinc, iron and selenium, and combining them risks exceeding safe upper intake levels
HO-1 has the potential to stimulate the angiogenesis by elevating the expression of several pro-angiogenic factors including VEGF, translational growth factor-1 (TGF-1), and stromal-derived factor-1 (SDF-1) [130, 131]
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Abbreviations 8-iso-PGF2-alpha: 8-iso-prostaglandin F2-alpha 8-OHdG: 8-oxodeoxyguanosine 8-OxOdG: 8-oxo-7,8- dihydro-2-deoxyguanosine AGE: Advanced glycation end-products ART: Assisted reproductive techniques ASK: Apoptosis signaling regulation kinase AT1-AA: Autoantibodies against AT1 receptor ATP: Adenine triphosphate BMI: Body mass index [Ca 2+ ] i : Intracellular calcium concentration CCE: Capacitative calcium entry cGMP: Cyclic guanosine monophosphate CRP: (C-reactive protein) CSH: Cysteamine Cu: Copper DDT: 1, 1, 1-trichloro-2, 2,-bis (4-chlorophenyl)-ethane EDTA: Ethylenediamine tetra-acetic acid eNOS/NOS III: Endothelial nitric oxide synthase ERK 1/2: Extracellular regulated kinase ET: Electron transfer ETC: Electron transport chain EtOH: Ethanol ER: Endoplasmic reticulum Fe 2+/3+ : Iron FF: Follicular fluid FSH: Follicular stimulating hormone GPx: Glutathione peroxidase GSH: Glutathione GSSG: Oxidized glutathione hCG: Human chorionic gonadotropin HDL: High-density lipoprotein HIF: Hypoxia-inducible factor HO: Heme oxygenase H 2 O: Water H 2 O 2 : Hydrogen peroxide HRT: Hormone replacement therapy HSP: Heat shock protein ICSI: Intracytoplasmic sperm injection IL: Interleukin iNOS/NOS II: Inducible nitric oxide synthase IUGR: Intrauterine growth restriction IVF: In-vitro fertilization JNK: c-Jun N -terminal kinases LH: Luteinizing hormone MAPK: Mitogen-activated protein kinases MDA: Malondialdehyde Mn: Manganese MTHFR: Methyl-tetra-hydrofolate reductase NAC: N-acetylcysteine NADPH: Nicotinamide adenine dinuleotide phosphate NK: Natural killer NOS: Nitric oxide synthase nNOS/nNOS I: Neuronal nitric oxide synthase NO: Nitric oxide NO 2 : Nitrogen dioxide O 2 : Oxygen OCPs: Organochlorine pesticides OH * : Hydroxyl radical ONOO : Peroxynitrite OPCs: Organophosphate compounds OS: Oxidative stress oxLDL: Oxidized low-density lipoprotein PCBs: Polychlorinated biphenyls PCOS: Polycycstic ovary syndrome PG: Prostaglandin PON 1: Paraoxonase-1 RNS: Reactive nitrogen species ROS: Reactive oxygen species RPL: Recurrent pregnancy loss Se: Selenium sFlt-1: Soluble receptor for vascular endothelial growth factor SHBG: Sex hormone binding globulin SO: Superoxide SOD: Superoxide dismutase STBM: Syncytiotrophoblast microvillus membrane TAC: Total antioxidant capacity TAS: Total antioxidant status TBARS: Thiobarbituric acid reactive substances THC: Delta-9-tetrahydrocannabinol TLR: Toll-like receptor TNF: Tumor necrosis factor Trx: Thioredoxin VEGF: Vascular endothelial growth factor Zn: Zinc
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