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The sinusoids and typical portal area as well as the hepatic strands were observed from the margin of the lobule to the central vein

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R min and R max were obtained by fitting the R values and the lysate-based GSH concentrations C GSH using equation: ( R R min )/( R max R )= k C GSH , in which k is a constant

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The apparent terminal t 1/2 following a 100-mg oral dose of sitagliptin was approximately 12.4 hours and renal clearance was approximately 350 mL/min