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however, the relatively small sample size may not adequately represent donor-to-donor variability

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Antioxid 11(12):2322 [DOI] [PMC free article] [PubMed] [Google Scholar] Miazek K, Beton K, liwiska A, Broek-Puska B (2022) The effect of -carotene, tocopherols and ascorbic acid as anti-oxidant molecules on human and animal in Vitro/In vivo studies: a review of research design and analytical techniques used

Understanding this biological process helps explain why effective treatments must address melanin production at the cellular level rather than simply attempting to bleach or lighten the skin's surface