Conversely, maintaining optimal vitamin C levels may help improve lung function and protect against conditions that affect the lungs, such as COPD ( Studies show that supplemental vitamin C may reduce the risk and duration of respiratory infections
PMID 1321584
In fact, the use of GSTP1 knockout mice demonstrated that loss of GSTP1 expression increases sensitivity to metabolic or environmental toxins and promotes mutations and cancer development ( FIGURE 2 Prostate cancer Promoter hypermethylation leading to epigenetic silencing of GSTP1 gene expression is frequently detected in prostate cancer cells, the most commonly diagnosed type of malignancy among men in Western European countries and the second cause of cancer-related deaths among men worldwide (Yang and Park, 2012
Upregulating antioxidant enzymes such as superoxide dismutase and catalase
iii) feedback regulation, involving the JNK/Beclin-1, NRF2/p62 and ROS/AMPK pathways, creating a bidirectional adaptive loop
Nl NF, Lalezari F, de Vries J, De Langen J, Aerts J, et al
