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GLP-1 is a naturally occurring hormone in our bodies, says Shauna Levy, M.D., director of Bariatric Surgery at Tulane University School of Medicine in TK

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These precedents highlight the need for indication-specific risk assessment and careful differentiation between mechanism-based toxicity and species-specific artifacts

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However, not all patients respond effectively to GLP-1R monoagonists, and higher doses aimed at increasing efficacy result in adverse gastrointestinal effects

The shortage of semaglutide is over as of early 2025, so that exception no longer works