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Semaglutide and tirzepatide (dual GLP-1/GIP agonist) follow similar appetite-suppression timelines, though tirzepatide may produce faster weight loss in some patients due to dual receptor activation

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When itching does occur, it may reflect a direct hypersensitivity to semaglutide itself, an immune response to the medication vehicle (the solution or coating agents), or a reaction to the injection site or oral formulation