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2014 Jan 16;13:5

they state that GLP-1 receptor agonists do not reduce abuse-related effects of opioids in assays of reward, reinforcement, or withdrawal (Bornebusch et al., 2019)

Melanotan-2 is a non-selective agonist

Patients should also be aware that folate supplementation should not be started before B12 deficiency has been treated, as doing so can precipitate or worsen neurological complications