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Hormone replacement therapy (HRT) remains the most effective treatment for moderate to severe hot flashes, typically reducing frequency by 7580%

Approval and additional research will define retatrutides role in holistic global obesity management

Some studies have suggested that the proliferation and apoptosis of granulosa cells (GCs) are the root causes of follicular development and atresia, with forkhead box protein O1 (FoxO1) playing an important role in promoting PCOS follicular atresia and GCs apoptosis (162, 163)

DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks

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Equally vital are reality checks, self-exclusion options, and limit-setting tools that help maintain healthy habits, especially during winning or losing streaks when emotions can cloud judgment