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While it was originally only used to treat diabetes, tirzepatide has been proven to help people lose weight and is now being prescribed under specific brand names for this purpose

Second, there are biological risks from the peptides themselves

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In contrast to many studies in which IGFBP-3 is tumor-suppressive, IGFBP-3 seems to act as an oncogene in gastrointestinal stromal tumors (GIST), in which low expression of miR-186 is proposed to increase metastasis through the upregulation of IGFBP-3 and several other metastatic genes [59]

J Ovarian Res 17:9 Helvaci N, Okan YB (2025) Polycystic ovary syndrome as a metabolic disease

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