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When to Contact Your Healthcare Provider While heartburn is common with GLP-1 medications, certain symptoms require medical attention: Severe or persistent heartburn that doesnt improve with lifestyle changes Difficulty or pain when swallowing Persistent nausea or vomiting Unintended weight loss Black, tarry stools or vomiting blood Chest pain (especially if its severe or accompanied by shortness of breathcall 911 if youre unsure whether its heartburn or a heart problem) Symptoms that significantly interfere with your daily life or sleep Your doctor may recommend prescription-strength medications or adjust your GLP-1 dose if symptoms are severe

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These combined effects create an effective tool for weight reduction, but they also mean the body becomes accustomed to these pharmacological signals during treatment