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For instance, in vitro studies using HepG2 cells treated with palmitic acid revealed that the GLP-1RA exendin-4 downregulated the expression of SREBP-1c and FAS, thereby attenuating steatosis (14, 15)

This article was edited by Nicola DallAsen and Leta Shy

The expression of HO-1, a cytoprotective enzyme critical for heme protein metabolism and ferroptosis, was also highly expressed in iron-accumulating renal cells and in mice with hypertensive nephropathy [257, 260, 261]

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These models showed alterations in tissue responsiveness and bone density under controlled settings

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