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Structurally, the synthetic fragment retains the active signaling properties of the parent molecule
10.1126/science.124.3220.484-a Science
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
Ogorek K, Nowak K, Wadych E, Ruzik L, Timerbaev AR, Matczuk M
For Heatmap of Partitioning Clustering in the first expression array experiment, genes exhibiting an absolute fold change of at least 2 and false discovery rate (FDR) of 0.05 or less in any pairwise comparison were chosen
Enrichment of cell cycle regulation in symbiotic branches Research on symbiont replication within the cnidarian host suggests that symbiont division is limited in symbiosis, as symbionts reared in culture media have higher replication rates than those in hospite ( 35,66
