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European Journal of Pharmacology, 440(2-3), 235-254

Lilly is studying retatrutide in several Phase 3 clinical trials to evaluate its potential efficacy and safety in obesity and overweight with at least one weight-related medical problem, type 2 diabetes, knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatotic liver disease

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Standard dosing protocol: Dose: 250-500mcg per injection Frequency: Twice daily (morning and evening) Duration: 4-8 weeks depending on injury severity Injection site: As close to injury as safely possible Weight-based dosing: Some people dose by body weight: 2.5-4 mcg per kilogram