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Available from: Xiao P, Wang H, Liu H, Yuan H, Guo C, Feng Y, et al

canonical entry for the trial's design, expected completion, and primary endpoint.) ClinicalTrials.gov

Use of insulin or sulfonylureas (hypoglycemia risk)

The gradual escalation serves two purposes: it allows the body to adapt to GLP-1 receptor activation (reducing nausea), and it permits glucagon receptor effects to build progressively without overwhelming metabolic pathways

It is worth noting that, consistent with experience across the GLP-1/GIP class, weight loss in people with type 2 diabetes may be somewhat smaller in magnitude compared with those with obesity alone

The excitement intensified with the release of initial phase 3 data from the comprehensive TRIUMPH clinical trial program