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Excess heme in sickle erythrocyte inside-out membranes: possible role in thiol oxidation

A typical research cycle runs 12 to 26 weeks of continuous daily dosing, followed by a washout period of at least 8 weeks

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L., Lefebvre, S

Research has shown that even in people without any underlying health conditions, when taking a 500 microgram oral supplement, only 10 micrograms (or 2%) is absorbed (Carmel, 2008)