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Whether the termination stemmed from safety signals, limited efficacy, or resource reallocation remains unclear

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however, evidence suggests that the specific pathogenic variant may have more influence on the phenotype than the complementation group.[47,67] The main distinguishing features appear to be the presence or absence of burning on minimal sun exposure, skin cancer, and progressive neurologic abnormalities

doi:10.1016/j.jplph.2007.10.015

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