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There is also a growing distinction between indications within coverage frameworks

Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes

Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness

There is a reason effective GLP-1 medication costs more: it took billions in R&D, multi-year clinical trials, and FDA regulatory review to develop

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