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Lilly made the announcement alongside results from two additional Phase 3 trials showing retatrutide delivered significant weight loss in adults with obesity and two serious complications: type 2 diabetes and established cardiovascular disease

(see codes in Supplementary Table S1) The follow-up period for all outcomes was defined as starting one day after the index fertility event and continuing for up to three years (1,095 days)

The primary endpoint was all-cause mortality at one year

PMID: 18936223

Without proper diet and exercise, the weight regain is fat, leaving you metabolically worse off than where you started

It also tells our brain that we are full, which slows digestion