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Adopting a holistic approach to weight management that includes a balanced diet, regular exercise, and lifestyle modifications remains crucial for sustainable and long-term weight loss success

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In two single-arm, open-label, multicentre, phase III trials, subcutaneous setmelanotide was effective in reducing body weight by at least 10% from baseline after approximately 1 year of treatment at individualised therapeutic doses in patients aged 6 years with POMC, PCSK1 or LEPR deficiency obesity