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The REWIND trial with dulaglutide included many patients without established ASCVD and demonstrated a consistent reduction in MACE, supporting a role in primary prevention, although the effect size was modest

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Biochem Pharmacol 70:18511860 Han TK, Proctor WR, Costales CL, Cai H, Everett RS, Thakker DR (2015) Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers

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