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Melatonin demonstrated neuroprotective, anti-inflammatory, and anti-apoptotic efficacy

Challenges like low selectivity, potential off-target effects, and incomplete mechanism insights explain why DYRK1A inhibitors, despite encouraging in vitro and animal model outcomes, have not advanced to clinical trials for diabetes therapy (Wang et al

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It will demand a structural transformation in how the NHS delivers weight management servicesmoving from short-term interventions to a chronic disease management model supported by robust primary care and specialist multidisciplinary teams