NAC definitely increases GSH synthesis, which neutralizes oxidant stress, thus interrupting the amplified oxidative/nitrosative stress cycle responsible for persistent JNK activation
The diagnosis of NAFLD relies on imaging [1] and histology, which enables the distinction to be made between simple fatty liver and NASH, where lobular inflammation and ballooning degeneration are also present [2, 3]
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Amer Soc Clin Onc 3:245, 1984
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