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The mechanistic foundation underlying this therapeutic versatility stems from the widespread distribution of the GLP-1 receptor and its pleiotropic signaling effects, which create a unified framework for understanding clinical benefits across seemingly disparate conditions

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Diabetes Res Clin Pract 183:109119 Phelps NH, Singleton RK, Zhou B et al (2024) Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults