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The standard dosing schedule begins at 0.25 mg weekly for four weeks, then increases to 0.5 mg weekly, with potential escalation to 1 mg or 2 mg weekly depending on glycaemic control and tolerability

Maes M, Bonifacio KL, Morelli NR, Vargas HO, Moreira EG, St Stoyanov D, et al

10.1210/en.2004-0764 138 MoranW.YongshengL.ShengL.JiagaoL

This falls within established therapeutic ranges and aligns with dosing used in anti-aging applications

You'll likely notice immediate hydration and a temporary glow after the first use

It was reported that CEO can potentially reduce inflammation by suppressing cyclooxygenase action [76]