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The endothelial cells also exhibit a comparatively significant number of mitochondria compared to other endothelial cells in the body

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It has therefore been postulated that gut-derived GLP-1 may not achieve sufficient concentration to stimulate distant cell GLP-1 receptors, and that an cell, rather than an enteroendocrine source of GLP-1, regulates insulin secretion under diabetic conditions (18)

ZHANG, Hongqiao

( Yanai, 2017 ) More importantly histamine plays a big role in the immune system