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A lack of intracellular cysteine, GSH, or SLC7A11 suppression reduces GPX4 activity, which can enhance lipid peroxidation and trigger ferroptosis (47)

The DSMB meets on an agreed timeline based on recruitment to review safety and efficacy data in a group-blinded fashion and may request unblinding of the data as needed to ensure subject safety

For example, those with amyotrophic lateral sclerosis (ALS) are advised not to supplement with BCAAs as it may impact cells in the nervous system

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Throughout his career, Marcos has led complex organizations across the United States, Latin America, Europe, and Asia, building strong leadership teams and translating strategy into disciplined execution