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However, balance is key

Some patients possess a higher natural tolerance and will not experience a significant drop in hunger until their dosage is increased to 0.5 mg, 1.0 mg, or higher in the subsequent months

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This can be particularly useful for men with secondary hypogonadism, where the issue lies in the signaling from the brain to the testes

As expected, treatment with DEM, started at 72 hours after knock-down initiation, leads to a significantly reduced response compared to siCtrl (Fig 3A)

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