The following sections explore practical, evidence-informed approaches to supporting your body's endogenous GLP-1 production through nutrition, lifestyle modification, and physical activity
NICE approved semaglutide (Wegovy) for weight management in specialist NHS weight management services in 2023 (TA875), but availability is limited to patients with: BMI 35 kg/m with at least one weight-related comorbidity, or BMI 30 kg/m with exceptional circumstances Lower BMI thresholds apply for people from some minority ethnic groups (typically 27.5 kg/m) Participation in a specialist weight management programme Treatment limited to a maximum of 2 years Access varies by region due to local integrated care board (ICB) implementation decisions and limited NHS specialist service capacity
Plus, the natural hormone breaks down quickly, within minutes, so its effects dont last long unless consistently supported
Berberine is a compound shown to stimulate GLP-1 secretion and improve insulin sensitivity
36 Several other recent studies also confirmed that tirzepatide treatment is superior to other GLP-1 RAs and placebo in promoting meaningful weight loss
You're Losing Weight Right Now: What Should You Actually Be Doing About Your Bones
