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(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle

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Astrocytic VEGFA: an essential mediator in blood-brain-barrier disruption in Parkinsons disease

Its formation results in activation of initiator caspase-8 with further downstream recruitment of executioner caspase-3 by limited proteolysis [73, 75]