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Nausea is the most common adverse effect , occurring in approximately 40-50% of patients taking GLP-1 receptor agonists, though rates vary by product and dose according to clinical trials (STEP trials for semaglutide

doi: 10.1007/s00125-016-4142-x 78 ChouICWangCHLinWDTsaiFJLinCCKaoCH

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Main outcome parameters and results: The main efficacy parameter was the effect of treatment on 6- and 12-month changes from baseline in nerve conduction velocity (NCV) and amplitude in the sensory (ulnar, sural and median) and motor (median, ulnar and peroneal) nerves

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