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To assess potential organ toxicity, an extensive toxicity analysis was carried out

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A microdose that seems trivially small after one injection becomes pharmacologically relevant after four to five weeks of accumulation

There are currently no randomised controlled trials evaluating GLP-1 receptor agonists as a treatment for rheumatoid arthritis, and these medications are not licensed or recommended for this indication by the MHRA, NICE, or the European Medicines Agency (EMA)

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However, the two orientations of KA, which are demonstrated by crystallography and in silico simulations (Figs 3 and 4), support the mixed inhibition mechanism, which is confirmed by our kinetic experiments (Fig