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The number of adhered PBMCs was counted with the ImageJ cell counter plugin

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Following sublingual administration, Drug A is 100 % bioavailable while following rectal administration, Drug A bioavailability is between 40 and 100 %, depending how far up the rectum the drug product is inserted Measurement of Bioavailability For intravenous injection, the whole of drug dose is delivered directly into the systemic circulation, thus it will always have 100 % bioavailability (F = 1) and the maximal plasma concentration (C max ) is reached instantaneously (T max = 0 min)

In some embodiments, the otic formulation or composition comprises about 17% by weight of the cholesterol

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Lyophilized Material Appearance Lyophilized material may appear cracked, fragmented, chipped, or loose within the vial