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Gradual escalation minimizes GI side effects such as nausea and vomiting, and is correlated with better long-term adherence
Severity is typically described as mild to moderate
Marshall-Goebel K, Macias BR, Kramer LA, Hasan KM, Ferguson C, Patel N, et al
These effects vary from person to person, but they are strongest when starting the medication, increasing the dose, or taking it together with anything else that depresses the central nervous system
This is one of many areas where ongoing peptide research and clinical studies continue to expand our understanding