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1.6 Biochemical and metabolic profiling The pathogenesis of neurodegenerative disorders generally involves a complex physiopathology that includes age-related changes, abnormal function and accumulation of brain proteins, inflammation, disruption of energy homeostasis, hormonal imbalances, metabolic imbalances, DNA damage, among other processes (Gadhave et al., 2024)

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68 In the cerebellum, 8-oxo-dG was negatively associated with GSH/GSSG in the combined case and control cohort (Figure 3)

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