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However, insulin sensitivity and glucose tolerance were maintained, likely owing to an increased conversion of saturated fatty acids (known to cause insulin resistance) to monounsaturated fatty acids mediated by stearoyl-CoA desaturase-1 (SCD1) [52]

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As of early 2025 the FDA had logged more than 320 adverse-event reports tied to compounded tirzepatide

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Hyperglycaemia can also elevate levels of tumoir necrosis factor (TNF)- and interleukin (IL)-6, cytokines linked to increased osteoclast activity

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