Ponticelli, C
Therefore, ferroptosis sensitivity may depend on the glucose starvation status, the level of intracellular NADPH, KG, or glutamine and extracellular cystine, and the expression level of xCT in each cancer cell [16,26,46,58]
GSH depletion does not induce mitochondrial superoxide or alter mitochondrial mass in RPE cells It has been suggested that mitochondria are predominant source of ROS upon H 2 O 2 -induced oxidative stress 7
Apart from the classical antioxidant role, GSH also has several organelle-specific functions discussed in detail by Lushchak (2012)
On the one hand, it becomes a drug with no pharmacological activity (inactivation)
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight