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The article explains that transdermal estradiol patches bypass hepatic first-pass processing, which reduces changes to lipids and clotting factors compared with oral estrogen, so the transdermal route generally pairs more safely with GLP-1 medications
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Briefly, an inverse correlation between IGF-1 (IGF-1/IGFBP-3 ratio) circulating levels and several markers for obesity, MetS, T2D, and CVD has been found
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