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This co-exposure causes intestinal barrier dysfunction and gut microbiota dysbiosis, driving synergistic liver injury via the gut-liver axis

They're often considered alternatives but they actually work quite differently

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Phase (Ph) I study of the safety and efficacy of the cMET inhibitor capmatinib (INC280) in patients (pts) with advanced cMET + non-small cell lung cancer (NSCLC)

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Disadvantages: The high sensitivity of cleavable linkers also brings certain risksif the design is not precise enough, non-target environments in circulation may trigger premature drug release