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10 Risk factors advanced age, polypharmacy, autonomic nervous system disorders, neurological injury (SCI-especially cervical or T6 and above and complete, CVA, peripheral neuropathies), CVD (CHF, MI, arrhythmias, AS), volume depletion, electrolyte imbalance, prolonged bed rest, rapid postural changes, heat exposure, ETOH, Renal disease and other comorbidities as listed under primary and secondary causes of OH

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It was hypothesized that increased levels of melanin would protect against high levels of UV radiation